9%, 95% CI, 11.6%-32.0%), studies that used serological tests to exclude H.pylori infection (27.5%, 95% CI, 20.1%-36.4%), and studies where non-response to eradication therapy was determined at <12months after treatment (27.0%, 95% CI, 15.5%-42.7%). Meta-regression analysis revealed that the pooled estimate was not significantly different in terms of the characteristics of individual studies.

Although the complete remission rate after eradication therapy is not high, it can be used as an initial treatment option in a subset of patients with H.pylori-negative gastric MALT lymphoma. Further studies to identify subgroups of patients who may benefit from eradication therapy are needed.

Although the complete remission rate after eradication therapy is not high, it can be used as an initial treatment option in a subset of patients with H. pylori-negative gastric MALT lymphoma. Further studies to identify subgroups of patients who may benefit from eradication therapy are needed.Cu-CHA is the state-of-the-art catalyst for the Selective Catalytic Reduction (SCR) of NOx in vehicle applications. Although extensively studied, diverse mechanistic proposals still stand in terms of the nature of active Cu-ions and reaction pathways in SCR working conditions. Herein we address the redox mechanism underlying Low-Temperature (LT) SCR on Cu-CHA by an integration of chemical-trapping techniques, transient-response methods, operando UV/Vis-NIR spectroscopy with modelling tools based on transient kinetic analysis and density functional theory calculations. We show that the rates of the Reduction Half-Cycle (RHC) of LT-SCR display a quadratic dependence on CuII , thus questioning mechanisms based on isolated CuII -ions. We propose, instead, a CuII -pair mediated LT-RHC pathway, in which NO oxidative activation to mobile nitrite-precursor intermediates accounts for CuII reduction. These results highlight the role of dinuclear Cu complexes not only in the oxidation part of LT-SCR, but also in the RHC reaction cascade.

It was aimed to compare open versus robotic-assisted radical cystectomy (RARC) with intracorporeal ileal conduit (ICIC), versus RARC with extracorporeal ileal conduit (ECIC) formation for bladder cancer.

Open, RARC-ECIC and RARC-ICIC groups were compared in terms of patient demographics, operative and postoperative parameters, pathological parameters, complications and functional outcomes.

Mean operative times were lower in the RARC-ECIC group (p=0.004). Mean estimated blood loss was significantly lower (p<0.01) in the robotic groups. The blood transfusion was lower in RARC-ICIC groups (p<0.001). Rates of stage pT3-4 disease were the highest in the RARC-ICIC group (p=0.004). LOS was significantly shorter in the RARC-ICIC group (p=0.01). Numbers of Clavien 3-5 complications were lower in the robotic groups (p=0.012).

RARC and ICIC is a complex procedure involving an increased operation time but with the advantages of lower estimated blood loss, transfusion rates, complications and hospital stays compared with open surgery.

RARC and ICIC is a complex procedure involving an increased operation time but with the advantages of lower estimated blood loss, transfusion rates, complications and hospital stays compared with open surgery.

The increased risk of upper gastrointestinal bleeding (UGIB) related to direct oral anticoagulants (DOACs) as compared to vitamin K antagonists (VKA) remains debated.

To describe the epidemiology and outcomes of UGIB in patients treated with oral anticoagulants.

A prospective, multicentre study in French general hospitals enrolled all consecutive patients with UGIB during one year. Patients treated with oral anticoagulants were retrieved from the cohort. Main outcomes were mortality and rebleeding during the first 6weeks and need for non-endoscopic treatment (surgery or interventional radiology).

Among the 2498 patients included, 475 (19%) had an oral anticoagulant, mostly with VKA (267 patients [56.2%]). Baseline characteristics were similar between the groups except for renal failure and cirrhosis that were more prevalent in the VKA group. Gastroscopy was normal in 73 patients (15.3%); peptic lesions were the main cause of UGIB (n=233, 49%). Endoscopic treatment was performed in 128 patients (26.9%), leading to bleeding resolution in 74% (n=95). Mortality rate at 6weeks was 12.4% (59 patients), and was higher in the VKA group compared to DOACs (16.1% vs 7.8%, P<0.01). By multivariate analysis, only the Charlson index≥5 and UGIB occurrring in in-patients were independently associated with mortality. Rebleeding (56 patients [11.8%]) and need for non-endoscopic treatment (18 patients [3.8%]) were not associated with the type of anticoagulant.

DOACs do not alter outcomes of UGIB as compared to VKA. Comorbidities and associated treatment are the most important factors worsening the prognosis of UGIB.

DOACs do not alter outcomes of UGIB as compared to VKA. Comorbidities and associated treatment are the most important factors worsening the prognosis of UGIB.Herein, we present a simple, cost-effective, and robust strategy for the in-situ preparation of Zn-Al layered double oxides-anodized aluminum thin film via a facile hydrothermal method, followed by calcination treatment of the Zn-Al layered double hydroxide in the air atmosphere. The in-situ prepared Zn-Al layered double oxide-anodized aluminum film was implemented as sorbent for thin film microextraction of four selected chlorophenols (4-chlorophenol, 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol), followed by high-performance liquid chromatography-ultraviolet detection. The different variables of the thin film microextraction were screened via Plackett-Burman design and then optimized through Box-Behnken design. Under the optimum condition, the method showed good linear ranges (0.2-200 μg/L) with the coefficient of determinations higher than 0.9938. The calculated limit of detections were between 0.07 and 0.56 μg/L. Relative standard deviations of the method for determination of the analytes at 5 μg/L concentration level (n = 3) were ranged from 3.5 to 3.9% (as interday). The enrichment factors were between 39 and 58. selleck kinase inhibitor This extraction method was demonstrated to be fast, efficient, and convenient. To study the capability of the developed method for real sample analysis, tap, well, river, and two types of wastewater samples were satisfactorily analyzed.