61), psychiatric symptomatology (RR=1.44) and (mild) challenging behaviours (RR=4.58).

Further efforts are needed to provide adequate mental health care, specifically to improve PM treatment regarding amount, indication and the consideration of non-psychopharmacological treatment options.

Further efforts are needed to provide adequate mental health care, specifically to improve PM treatment regarding amount, indication and the consideration of non-psychopharmacological treatment options.

There is lack of evidence and research understanding among women’s lived experiences following first acute coronary syndrome, thus their recovery process remains poorly understood. To date research has largely focused on men’s experience of acute coronary syndrome while this area of health care and recovery has considerable impact on women’s health and quality of life. Our aim was to review the literature exploring lived experience of women following first acute coronary syndrome.

Integrative review of the literature.

We searched PubMed, MEDLINE, EMBASE, CINAHL and Scopus from 2008-2018 for articles published in English.

Of 1675 publications identified, 18 qualitative, quantitative, and mixed method studies met our inclusion criteria. Quality of included studies was assessed using Joanna Briggs Institute quality assessment tools. Findings were integrated using thematic synthesis.

Experiencing acute coronary syndrome was reported to have significant impacts on women’s lives. The most common issues res to the current body of knowledge by addressing women’s physical, psychosocial, and sexual state following acute coronary syndrome. Improvement in women’s quality of life after acute coronary syndrome necessitates further research which ultimately results in better management and treatment of women and their recovery following first acute coronary syndrome.

To determine the potential anti-inflammatory effect of a multimodal periodic fasting programme on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS).

A total of 47 patients were recruited and hospitalized in an integrative ward for an intensified two-week multimodal fasting, diet and lifestyle programme. Patients were periodontally examined at baseline (t1), after the 2-week fasting protocol (t2) and, subsequently, 4months after fasting (t3). The following parameters were determined periodontal screening index (PSI), bleeding on probing (BOP), gingival crevicular fluid volume (GCF), plaque index (PI), C-reactive protein (CRP), blood pressure (BP), waist circumference (WC), fasting glucose (FGLU), triglycerides (TRG), high-density lipoprotein (HDL) and HbA1c.

A total of 28 female and 8 male patients fulfilled the defined criteria for MetS and were analysed separately by gender. At t2, BOP and GCF were reduced when compared to t1 (median t2=39; t1=33.1%; p<.001 and t2=73.9; t1=59.3 Periotron units p=.02, respectively). BOP reduction correlated to FGLU (R=.37, p=.049) and weight reduction (R=.4, p=.04).

This study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.

This study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.

Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterised by malignant transformation of a pre-existing benign trichoblastoma, and are subdivided histologically into low-grade and high-grade tumours. Whereas morphologically low-grade trichoblastic carcinomas show indolent behaviour, morphologically high-grade trichoblastic carcinomas have been associated with a poor prognosis, but little is known about their true biological potential. The aim of this study was to better define the clinicopathological features and outcomes of morphologically high-grade trichoblastic carcinomas.

Four high-grade trichoblastic carcinomas were retrieved from departmental files, and the clinical and histopathological features and follow-up were recorded. The tumours presented as nodules on the scalps, necks and shoulders of adults (median age, 40years; range, 30-55years) with a female predominance of 31. Three patients had a longstanding history with recent change. Histologicallchoblastoma or trichoepithelioma. Despite the concerning histological features of the malignant component, the tumours appear to be less aggressive than previously thought.

Autophagic vacuolar myopathies (AVMs) are an emerging group of heterogeneous myopathies sharing histopathological features on muscle pathology, in which autophagic vacuoles are the pathognomonic morphologic hallmarks. Glycogen storage disease type II (GSDII) caused by lysosomal acid α-glucosidase (GAA) deficiency is the best-characterised AVM.

This study aimed to investigate the mutational profiling of seven neuromuscular outpatients sharing clinical, myopathological and biochemical findings with AVMs.

We applied a diagnostic protocol, recently published by our research group for suspected late-onset GSDII (LO-GSDII), including counting PAS-positive lymphocytes on blood smears, dried blood spot (DBS)-GAA, muscle biopsy histological and immunofluorescence studies, GAA activity assay and expression studies on muscle homogenate, GAA sequencing, GAA multiplex ligation-dependent probe amplification (MLPA) and whole exome sequencing (WES).

The patients had a limb girdle-like muscular pattern with persistentered as AVM markers together with LC3/p62-positive autophagic vacuoles.

The efficacy and safety of cow’s milk (CM) low-dose oral immunotherapy (LOIT) at one-year follow-up have been previously reported. Disufenton chemical structure We investigated the outcome of fixed long-term LOIT in children with severe CM allergy.

Children with positive reactions to oral food challenge (OFC) with 3mL CM were included. The LOIT group (n=33) ingested up to 3mL CM for 1year. After a two-week CM avoidance, 3 and 25mL OFCs were performed. Children with positive reactions continued with 3mL ingestion, with OFCs repeated yearly. Regular home consumption of 25mL CM after passing the OFCs was defined as 25mL short-term unresponsiveness (25mL STU). The historical control group (n=16) with reactions to 3mL OFC eliminated daily CM ingestion.

The proportion of 25mL STU in the LOIT group was 27%, 52%, and 61% after 1, 2, and 3years, respectively, and the 3-year percentage was significantly higher than that in the historical control group (13%, P=.002). In the LOIT group, only one child developed severe symptoms. Furthermore, in this group, CM- and casein-specific immunoglobulin E (sIgE) levels decreased significantly and casein-specific IgG and IgG

levels increased significantly after 3years, whereas the historical control group presented no significant change in these parameters.