Most importantly, morin hydrate has the potential to modulate a variety of biological networks. Therefore, it can be predicted that this therapeutically potent compound could serve as a dietary agent for the expansion of human health and might be helpful for the development of the novel drug in the future. However, due to the lack of clinical trials, special human clinical trials are needed to address the effects of morin hydrate on various life-threatening disparities to recommend morin and/or morin-rich foods with other foods or bioactive dietary components, as well as dose-response interaction and safety profile.The aim of this study was to prepare, characterize, and determine the in vitro anticancer effects of platinum-doped magnesia (Pt/MgO) nanoparticles. The chemical compositions, functional groups, and size of nanoparticles were determined using X-ray diffraction, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, transmission electron microscopy, and scanning electron microscopy. Pt/MgO nanoparticles were cuboid and in the nanosize range of 30-50 nm. The cytotoxicity of Pt/MgO nanoparticles was determined via the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the human lung and colonic cancer cells (A549 and HT29 respectively) and normal human lung and colonic fibroblasts cells (MRC-5 and CCD-18Co repectively). The Pt/MgO nanoparticles were relatively innocuous to normal cells. this website Pt/MgO nanoparticles downregulated Bcl-2 and upregulated Bax and p53 tumor suppressor proteins in the cancer cells. Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. Thus, the anticancer effects of Pt/MgO nanoparticles were attributed to the induction of oxidative stress and apoptosis. The study showed the potential of Pt/MgO nanoparticles as an anti-cancer compound.

We had reported that cajanolactone A (CLA) from Cajanus cajan dose-dependently inhibited ovariectomy-induced obesity and liver steatosis in mice, showing potential to prevent postmenopausal obesity and fatty liver. In this study, the role of CLA in the regulation of energy and lipid homeostasis was investigated.

Ovariectomized mice treated with CLA or vehicle for 12 weeks were performed a 48h monitoring for energy metabolism and food uptake. After that, hypothalami, perigonadal (pWATs), inguinal (iWATs) and brown (BATs) adipose tissues, livers, sera, and fecal and cecal contents were collected and analyzed.

In CLA-treated mice, we observed reduced food uptake; increased energy expenditure; inhibited expression of orexigenic genes (ORX, ORXR2, pMCH and Gal) in the hypothalami, of lipogenic genes (CD36, SREBP-1c, ChREBP, PPARγ) in the livers, and of lipid storage proteins in the WATs (FSP27, MEST and caveolin-1) and livers (FSP27, Plin2 and Plin5); stimulated expression of metabolism-related proteins (pATGL and Echs1) in the adipose tissues and of thermogenic protein (UCP1) in the inguinal WATs; increased BAT content; increased mitochondria in the pWATs and livers; inhibited angiogenesis in the pWATs; and altered gut microbiome diversity with an increased abundance of Bacteroides.

CLA prevents ovariectomy-induced obesity and liver steatosis via regulating energy intake and lipid synthesis/storage, promoting UCP1-dependent heat production, and protecting the mitochondrial function of hepatocytes and adipocytes. The improved gut microecology and inhibited angiogenesis may also contribute to the anti-obese activity of CLA.

CLA prevents ovariectomy-induced obesity and liver steatosis via regulating energy intake and lipid synthesis/storage, promoting UCP1-dependent heat production, and protecting the mitochondrial function of hepatocytes and adipocytes. The improved gut microecology and inhibited angiogenesis may also contribute to the anti-obese activity of CLA.In this paper, two donor (D)-acceptor (A) type of small organic fluorescent molecules (T1 and T2) based on terpyridine group are synthesized, characterized and used as colorimetric/fluorometric dual-channel probes towards diethylchlorophosphate (DCP, the mimic of chemical warfare agent sarin) not only in solution but also in gas phase featuring instantaneous responses, excellent recyclability, high selectivity and sensitivity. Interestingly though the discriminated units of both chemosensors are terpyridine, their fluorescent responded signals are different, which is due to the different electron-donating substituents of T1 and T2 caused the different responded mechanism to DCP. And the possible sensing mechanism was proved by using nuclear magnetic resonance (1H NMR, 31P NMR) spectra and natural transition orbitals calculations. Furthermore, facile testing filter paper-constructed strips with the visualization of colorimetric/fluorometric dual-channel responses based on T1 and T2 have been fabricated for real-time, on-site high selective and sensitive, recyclable monitor of DCP vapor.Cold plasma is considered a highly competitive advanced oxidation process for the removal of organic pollutants from soil. Herein, we describe for the first time the combination of in-soil generated plasma micro-discharges with the advantageous high voltage nanosecond pulses (NSP) towards the high-efficient degradation of trifluralin in soil. We performed a detailed parametric analysis (pulse frequency, pulse voltage, soil thickness, soil type, energy efficiency) to determine the optimum operational conditions. High trifluralin degradation was achieved even at the higher soil thickness, indicating that the production of plasma discharges directly inside the soil pores enhanced the mass transfer of plasma reactive oxygen and nitrogen species (RONS) in soil. The energy efficiency achieved was outstanding, being up to 2-3 orders of magnitude higher than those reported for other plasma systems. We identified the intermediate degradants and proposed the most dominant degradation pathways whereas a thorough exhaust gases analysis, optical emission spectroscopy (OES) and active species inhibition by using trapping agents revealed the main RONS involved. This effort constitutes a significant advancement in the “green” credentials and application of plasma-induced degradation of pollutants as it describes for the first time the removal of the highly harmful and toxic pesticide trifluralin from soil and provides a novel perspective towards the future development of cold plasma-based soil remediation technologies.