The characterization of the CaP-carboplatin biomaterials showed heterogeneous crystalline precipitation of the drug, and no morphological modifications of the CaPs biomaterials. The in vitro release profile of carboplatin from CaPs was evaluated by the ultraviolet-visible (UV-Vis) method. selleck chemical The curves showed a burst release of upon 60% of carboplatin loaded followed by a slow-release of the drug for the time of the study. The results were typical of a low-interaction system and physisorption mechanism. The high-vacuum method permitted to load the high amount of carboplatin drug on the surface of the biomaterials despite the low interaction between carboplatin and CaPs.The COVID-19 pandemic has interrupted everyday life virtually everywhere in the world, enabling real-life research on threat-and-defense processes. In a survey conducted within the first days of implementing social distancing measures in Austria and Germany, we aimed to explore the pathways from threat perception to preferences of defense strategies. We found that anxiety, approach-related affect, and reactance were specifically elicited by motivational (vs. epistemic) discrepancies. In a second step, we tested the mediating effect of anxiety, approach-related affect, and reactance on preferences regarding personal-social and concrete-abstract defenses. Experiencing anxiety was related to interest in security-related actions, and approach-affect was related to both personal projects and social media use. Participants experiencing reactance were more inclined to pursue personal projects (personal-abstract) and less interested in security-related (personal-concrete) actions. They also showed marginally lower system justification (social-abstract). Additionally, we examined the relationship of loneliness with defense strategies, showing that loneliness was associated with lower system justification and security behaviors. The results suggest that individuals deal with threat in their own ways, mostly depending on affective state and motivational orientation Anxiety was related to security, approach-state to action (both social and personal), reactance to derogation of the system and disregard for security, while loneliness was associated with inaction.The entry of SARS-CoV-2 into target cells requires the activation of its surface spike protein, S, by host proteases. The host serine protease TMPRSS2 and cysteine proteases Cathepsin B/L can activate S, making two independent entry pathways accessible to SARS-CoV-2. Blocking the proteases prevents SARS-CoV-2 entry in vitro. This blockade may be achieved in vivo through ‘repurposing’ drugs, a potential treatment option for COVID-19 that is now in clinical trials. Here, we found, surprisingly, that drugs targeting the two pathways, although independent, could display strong synergy in blocking virus entry. We predicted this synergy first using a mathematical model of SARS-CoV-2 entry and dynamics in vitro. The model considered the two pathways explicitly, let the entry efficiency through a pathway depend on the corresponding protease expression level, which varied across cells, and let inhibitors compromise the efficiency in a dose-dependent manner. The synergy predicted was novel and arose from effects of the drugs at both the single cell and the cell population levels. Validating our predictions, available in vitro data on SARS-CoV-2 and SARS-CoV entry displayed this synergy. Further, analysing the data using our model, we estimated the relative usage of the two pathways and found it to vary widely across cell lines, suggesting that targeting both pathways in vivo may be important and synergistic given the broad tissue tropism of SARS-CoV-2. Our findings provide insights into SARS-CoV-2 entry into target cells and may help improve the deployability of drug combinations targeting host proteases required for the entry.With the development of web maps, people are no longer satisfied with fixed and limited scale map services but want to obtain personalized and arbitrary scale map data. Continuous map generalization technology can be used to generate arbitrary scale map data. This paper proposes a morphing method for continuously generalizing linear map features using shape context matching and hierarchical interpolation (SCM-HI). More specifically, shape characteristics are quantitatively described by shape context on which shape similarity is measured based on a chi-square method; then, two levels of interpolation, skeleton and detail interpolations, are employed to generate the geometry of intermediate curves. The main contributions of our approach include (1) exploiting both the geometry and spatial structure of a vector curve in shape matching by using shape context, and (2) preserving both the main shape structure as-rigid-as-possible and local geometric details as gradual and smooth as possible for intermediate curves by hierarchical interpolation. Experiments show that our method generates plausible morphing effects and can thus serve as a robust approach for continuous generalization of linear map features.Litter and plastic pollution in the marine environment is of major concern when considering the health of ocean ecosystems, and have become an important focus of ocean research during recent years. There is still significant uncertainty surrounding the distribution and impact of marine plastic litter on ocean ecosystems, and in particular on the nano- and microplastic fractions that are difficult to observe and may be harmful to marine organisms. Current estimates of ocean plastic concentrations only account for a small fraction of the approximated 8 million tons of plastic litter entering the oceans on an annual basis. Here, we present the distribution of 100-500 μm microplastic particles within the ocean mixed layer, covering a significant fraction of the ocean, in a near-synoptic survey. During The Ocean Race 2017/2018 edition (formerly known as Volvo Ocean Race), two yachts served as ships of opportunity that regularly took samples of microplastics on a regular schedule during their circumnavigation. This effort resulted in information on microplastic distribution along the race track in the ocean’s upper, well-mixed, layer. We found concentrations ranging from 0-349 particles per cubic meter, but with large spatial variability. There was a tendency toward higher concentrations off south-western Europe and in the southwest Pacific, and indications of long-range transport of microplastic with major ocean currents.