Treatment of leiomyoma smooth muscle cell and myometrial smooth muscle cell spheroids with the TDO2 inhibitor 680C91 but not the IDO1 inhibitor epacadostat significantly repressed cell proliferation and the expression of collagen type I (COL1A1) and type III (COL3A1) in a dose-dependent manner; these effects were more pronounced in leiomyoma…[Read more]

Treatment of leiomyoma smooth muscle cell and myometrial smooth muscle cell spheroids with the TDO2 inhibitor 680C91 but not the IDO1 inhibitor epacadostat significantly repressed cell proliferation and the expression of collagen type I (COL1A1) and type III (COL3A1) in a dose-dependent manner; these effects were more pronounced in leiomyoma…[Read more]

While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. Sodium oxamate We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis.

We used a…[Read more]

While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. Sodium oxamate We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis.

We used a…[Read more]

While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. Sodium oxamate We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis.

We used a…[Read more]

While Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. Sodium oxamate We tested whether dysregulation of cholesterol catabolism, through its conversion to primary bile acids (BAs), was associated with dementia pathogenesis.

We used a…[Read more]

Finally, some perspectives and future directions are proposed for further catalytic performance enhancement and deeper understanding of catalyst design. It is believed that iterative improvements based on the understanding of mechanisms and fundamental design principles are essential to realize the applications of efficient transition metal-based…[Read more]

Finally, some perspectives and future directions are proposed for further catalytic performance enhancement and deeper understanding of catalyst design. It is believed that iterative improvements based on the understanding of mechanisms and fundamental design principles are essential to realize the applications of efficient transition metal-based…[Read more]

Finally, some perspectives and future directions are proposed for further catalytic performance enhancement and deeper understanding of catalyst design. It is believed that iterative improvements based on the understanding of mechanisms and fundamental design principles are essential to realize the applications of efficient transition metal-based…[Read more]

Finally, some perspectives and future directions are proposed for further catalytic performance enhancement and deeper understanding of catalyst design. It is believed that iterative improvements based on the understanding of mechanisms and fundamental design principles are essential to realize the applications of efficient transition metal-based…[Read more]

The use of AZM was not associated with mortality in Covid-19 patients (OR = 0.96, 95% CI 0.88-1.05, p = 0.317 based on the random-effect meta-analysis). The use of AZM was not associated with need for invasive mechanical ventilation (OR = 0.96, 95% CI 0.49-1.87, p = 0.85) and length of stay (Δ = 1.11, 95% CI -2.08 to 4.31, p = 0.49). The results…[Read more]

The use of AZM was not associated with mortality in Covid-19 patients (OR = 0.96, 95% CI 0.88-1.05, p = 0.317 based on the random-effect meta-analysis). The use of AZM was not associated with need for invasive mechanical ventilation (OR = 0.96, 95% CI 0.49-1.87, p = 0.85) and length of stay (Δ = 1.11, 95% CI -2.08 to 4.31, p = 0.49). The results…[Read more]