This study investigates extremes of wave climate in the western North Pacific (WNP) as significant responses to modes of climate variability the El Niño-Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO). Few studies have explicitly investigated significant wave height in this context, and hence, the aim of the present study is to investigate and quantify the responses to a simulated wave data set over the WNP from 1979-2009 by focusing on the combined influences of the ENSO and PDO during the boreal summer. We conducted a composite analysis of sea surface temperatures, sea-level pressure, and extreme anomalies of wave power density (Pw) on different phase combinations of the ENSO and the PDO, and also analyzed the effects of a latitudinal shift of the ITCZ for composite samples with respect to simulated tropical storm (TS) activities. The results demonstrate that the ENSO played a primarily positive role in intensifying anomalous wave climate, while the PDO had the opposite effect. The responses of the peak wave-period were linked to a strengthened anomalous low-pressure and a cooling of sea surface temperature anomalies. The PDO played a significant role in strengthening or weakening of the effects of the ENSO on Pw, thus confirming the findings of previous studies. We found that responses were dependent on whether ENSO and PDO were in or out of phase. These responses can be described by a strengthening of the southeast trade winds that blow across the equator with respect to a latitudinal shift of the Intertropical Convergence Zone (ITCZ). Our findings contribute to the understanding of a relationship between modes of climate variability and TS activities with respect to the status of the ITCZ over the WNP, which can be relevant factors in the lifetime of wave power and related wave parameters in the WNP during the boreal summer.HA (Hyaluronic acid) filler, the most commonly used dermal filler, causes several side effects. HA-PN (Hyaluronic acid-Polynucleotide), a new composite filler, has excellent biocompatibility and induces tissue regeneration. In this study, we compare the efficacies and safety profiles of these fillers. The characteristics of HA and HA-PN fillers were compared using scanning electron microscopy and rheometry. No morphological difference was noted between the fillers. However, the latter had higher viscosity and elasticity values. The HA-PN filler induced higher cell migration than the HA filler in a wound healing assay. It was also found to stimulate better collagen synthesis in human and mouse fibroblasts. The HA and HA-PN fillers were injected into SKH1 hairless mice to determine changes in their volume for up to 24 weeks. Increased cell migration and collagen synthesis were observed in mice injected with the HA-PN complex filler. Although the safety and durability of the HA and HA-PN fillers were similar, the latter induced a lower transient receptor potential vanilloid 4 expression and caused less stimulation upon injection. In conclusion, HA-PN complex fillers can stimulate fibroblast growth and facilitate volume growth and skin regeneration.An amendment to this paper has been published and can be accessed via a link at the top of the paper.The homology and evolution of the archosaur ankle is a controversial topic that has been deeply studied using evidence from both extinct and extant taxa. In early stem archosaurs, the astragalus and calcaneum form the ancestral proximal tarsus and a single ossification composes the centrale series. In more recent stem archosaurs, the centrale is incorporated to the proximal row of tarsals laterally contacting the astragalus. This bone is subsequently lost as an independent ossification before the last common ancestor of birds and crocodilians, but the evolutionary fate of this element remains mostly unexplored. Here, we integrate embryological and palaeontological data with morphogeometric analyses to test the hypothesis of loss of the centrale or, alternatively, its incorporation into the archosaurian astragalus. Our results support the latter hypothesis, indicating that the astragalus developed ancestrally from two ossification centres in stem archosaurs and that the supposed tibiale of bird embryos represents a centrale. This conclusion agrees with previous embryological studies that concluded that the tibiale never develops in diapsids.Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studies on Egyptian patients ion top of HCV. However these studies included small number of patients and did not assess the different stages of hepatocarcinogenesis. In the current study we assessed 1) the expression levels of Golgi protein 37(GP73),Midkine (MDK) and Dickkopf-1(DKK-1) proteins separately and in combination at different stages of hepatocarcinogenesis. GP73, MDK and DKK-1 proteins were assessed in 238 individuals divided into 4 groups (HCC, chronic HCV, and chronic HCV with cirrhosis and healthy subjects as a control) Serum levels of GP73, MDK, and DKK-1 were assessed in all subjects by ELISA. Serum levels of the studied markers were significantly higher in HCC compared to other groups (p  less then  0.001). The ROC curve analysis for the studied markers showed 1) 88.5% sensitivity, 80.6% specificity, 69% PPV, 93.5% NPV and (AUC 0.91)for MDK; 2) 93.6%, 86.9%, 77.7%, 96.5% for DKK-1. 3) 91%, 85%, 74.7%, 95% (AUC 0.96) for GP73 and 4) 74.4%, 84.4%, 69.9%, 87.1% (AUC 0.81) for AFP. Serum levels of GP73, MDK, and DKK-1 are comparable to AFP as promising predictor biomarkers for HCC patients from Egypt. A two markers panel including Gp73 and DKK-1 showed the highest specificity and sensitivity among different markers combinations.In this work, N,N’-bis(salicylidene)-(2-(3′,4′-diaminophenyl)benzothiazole) (named as “BTS”) system was studied about its excited-state intramolecular proton transfer (ESIPT) process. The analyses about reduced density gradient (RDG) reveal the formation of two intramolecular hydrogen bonds in BTS system. Bond lengths and angles, infrared (IR) vibrations as well as frontier molecular orbitals (MOs) using TDDFT method indicate that the strength of hydrogen bond should be enhanced in the S1 state. Particularly, hydrogen bond O1-H2···N3 undergoes larger variations compared with O4-H5···N6, which infers that hydrogen bond O1-H2···N3 may play a decisive role in the ESIPT process of BTS system. selleck inhibitor Given the two hydrogen bonds of BTS molecule, two types of potential energy curves have been constructed, which confirms that only single proton transfer process occurs due to lower energy barrier along with O1-H2···N3 rather than O4-H5···N6. This work not only presents a reasonable explanation for previous experiment, but also clarifies the specific ESIPT mechanism for BTS system.