Then, there is a common profile of injuries in canoeists Being a female, having more years of sports practice, and never executing stretching exercises are associated with predisposing factors to injuries.Acute kidney injury (AKI) is a common finding in patients with coronavirus disease 2019 (COVID-19) and has been associated with higher rates of death when compared to COVID-19 patients without kidney injury. Whereas the definitive pathogenesis of COVID-19-related AKI (CoV-AKI) is not clear, histopathologic evidence seems to point at multiple etiologies for the disease, including indirect and direct viral kidney injury. The high incidence of CoV-AKI, along with the aggressive clinical presentation of this entity, have increased the demands for kidney replacement therapies, rapidly overwhelming the supplies of healthcare systems even in major tertiary care centers. As a result, nephrologists have come up with alternatives to maximize the efficiency of treatments and have developed non-conventional therapeutic alternatives such as the implementation of acute peritoneal dialysis for critically ill patients. The long-term implications of CoV-AKI are yet unknown, though early studies suggest that around one third of the patients who survive will remain dependent on kidney replacement therapy. Nephrologists and healthcare workers need to be familiar with the clinical presentation and therapeutic challenges of CoV-AKI in order to develop strategies to mitigate the burden of the disease for patients, and for services providing kidney replacement therapies.Experimental characterization and validation of skin components in aircraft entails multiple evaluations (structural, aerodynamic, acoustic, etc.) and expensive campaigns. They require different rigs and equipment to perform the necessary tests. Two of the main dynamic characterizations include the energy absorption under impact forcing and the identification of modal parameters through the vibration response under any broadband excitation, which also includes impacts. This work exploits the response of a stiffened aircraft composite panel submitted to a multi-impact excitation, which is intended for impact and energy absorption analysis. Based on the high stiffness of composite materials, the study worked under the assumption that the global response to the multi-impact excitation is linear with small strains, neglecting the nonlinear behavior produced by local damage generation. Then, modal identification could be performed. The vibration after the impact was measured by high-speed 3D digital image correlation and employed for full-field operational modal analysis. Multiple modes were characterized in a wide spectrum, exploiting the advantages of the full-field noninvasive techniques. These results described a consistent modal behavior of the panel along with good indicators of mode separation given by the auto modal assurance criterion (Auto-MAC). Hence, it illustrates the possibility of performing these dynamic characterizations in a single test, offering additional information while reducing time and investment during the validation of these structures.This paper presents forced vibration analysis of a simply supported beam made of carbon nanotube-reinforced composite material subjected to a harmonic point load at the midpoint of beam. The composite beam is made of a polymeric matrix and reinforced the single-walled carbon nanotubes with their various distributions. In the beam kinematics, the first-order shear deformation beam theory was used. The governing equations of problem were derived by using the Lagrange procedure. In the solution of the problem, the Ritz method was used, and algebraic polynomials were employed with the trivial functions for the Ritz method. In the solution of the forced vibration problem, the Newmark average acceleration method was applied in the time history. In the numerical examples, the effects of carbon nanotube volume fraction, aspect ratio, and dynamic parameters on the forced vibration response of carbon nanotube-reinforced composite beams are investigated. see more In addition, some comparison studies were performed, with special results of published papers to validate the using formulations.α-Conotoxin GeXIVA[1,2] is a highly potent and selective antagonist of the α9α10 nicotinic acetylcholine receptor (nAChR) subtype. It has the advantages of strong efficacy, no tolerance, and no effect on motor function, which has been expected help patients with neuropathic pain. However, drug development for clinical use is severely limited owing to its instability. Lyophilization is applied as the most preferred method to solve this problem. The prepared lyophilized powder is characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR). Molecular simulation is also used to explore the internal distribution and forces formed in the system. The analgesic effect on paclitaxel-induced neuropathic pain following single and 14-day repeated administrations are evaluated by the von Frey test and the tail-flick test. Trehalose combined with mannitol in a ratio of 11 is employed as the excipients in the determined formulation, where trehalose acts as the stabilizer and mannitol acts as the bulking agent, according to the results of DSC, PXRD, and FTIR. Both GeXIVA[1,2] (API) and GeXIVA[1,2] lyophilized powder (formulation) could produce stable analgesic effect. These results indicated that GeXIVA[1,2] lyophilized powder could improve the stability and provide an effective strategy to push it into clinical use as a new analgesic drug.Environmental problems have always received immense attention from scientists. Toxicants pollution is a critical environmental concern that has posed serious threats to human health and agricultural production. Heavy metals and pesticides are top of the list of environmental toxicants endangering nature. This review focuses on the toxic effect of heavy metals (cadmium (Cd), lead (Pb), copper (Cu), and zinc (Zn)) and pesticides (insecticides, herbicides, and fungicides) adversely influencing the agricultural ecosystem (plant and soil) and human health. Furthermore, heavy metals accumulation and pesticide residues in soils and plants have been discussed in detail. In addition, the characteristics of contaminated soil and plant physiological parameters have been reviewed. Moreover, human diseases caused by exposure to heavy metals and pesticides were also reported. The bioaccumulation, mechanism of action, and transmission pathways of both heavy metals and pesticides are emphasized. In addition, the bioavailability in soil and plant uptake of these contaminants has also been considered.