For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group…[Read more]

For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group…[Read more]

For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group…[Read more]

For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group…[Read more]

Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limb threating ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk…[Read more]

Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limb threating ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk…[Read more]

Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limb threating ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk…[Read more]

Peripheral artery disease (PAD) affects more than 200 million patients worldwide and chronic limb threating ischemia (CLTI) is the most advanced stage of PAD with very high morbidity and mortality rates. Cardiovascular medicine is trending towards a more personalized approach where each individual patient will be managed according to specific risk…[Read more]

Sedentary behaviour for an average weekday was 6.4 hours, and weekends were 5.3 hours. Joint disease and severity type influenced the amount of activity undertaken, together with values for HAL and EQ-5D-5L. Twenty two types of activities were listed. CONCLUSION It is encouraging to see the amount of physical activity PWH participate in, however,…[Read more]

Sedentary behaviour for an average weekday was 6.4 hours, and weekends were 5.3 hours. Joint disease and severity type influenced the amount of activity undertaken, together with values for HAL and EQ-5D-5L. Twenty two types of activities were listed. CONCLUSION It is encouraging to see the amount of physical activity PWH participate in, however,…[Read more]

Sedentary behaviour for an average weekday was 6.4 hours, and weekends were 5.3 hours. Joint disease and severity type influenced the amount of activity undertaken, together with values for HAL and EQ-5D-5L. Twenty two types of activities were listed. CONCLUSION It is encouraging to see the amount of physical activity PWH participate in, however,…[Read more]

Sedentary behaviour for an average weekday was 6.4 hours, and weekends were 5.3 hours. Joint disease and severity type influenced the amount of activity undertaken, together with values for HAL and EQ-5D-5L. Twenty two types of activities were listed. CONCLUSION It is encouraging to see the amount of physical activity PWH participate in, however,…[Read more]

Antiphase masks were found to be more effective than random depth masks, requiring a lower mask-to-surface dot ratio to inhibit performance. For antiphase masks, performance improved with decreased cyclopean frequency, increased disparity amplitude, and/or an increase in the total number of stimulus dots. Although a cross-correlation model of…[Read more]

Antiphase masks were found to be more effective than random depth masks, requiring a lower mask-to-surface dot ratio to inhibit performance. For antiphase masks, performance improved with decreased cyclopean frequency, increased disparity amplitude, and/or an increase in the total number of stimulus dots. Although a cross-correlation model of…[Read more]

Antiphase masks were found to be more effective than random depth masks, requiring a lower mask-to-surface dot ratio to inhibit performance. For antiphase masks, performance improved with decreased cyclopean frequency, increased disparity amplitude, and/or an increase in the total number of stimulus dots. Although a cross-correlation model of…[Read more]

Antiphase masks were found to be more effective than random depth masks, requiring a lower mask-to-surface dot ratio to inhibit performance. For antiphase masks, performance improved with decreased cyclopean frequency, increased disparity amplitude, and/or an increase in the total number of stimulus dots. Although a cross-correlation model of…[Read more]

As of February 26, six patients had a negative RT-PCR for 2019-nCoV and were discharged. The median time from exposure to a negative RT-PCR was 14 days. CONCLUSIONS The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. Children who have a…[Read more]

As of February 26, six patients had a negative RT-PCR for 2019-nCoV and were discharged. The median time from exposure to a negative RT-PCR was 14 days. CONCLUSIONS The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. Children who have a…[Read more]

As of February 26, six patients had a negative RT-PCR for 2019-nCoV and were discharged. The median time from exposure to a negative RT-PCR was 14 days. CONCLUSIONS The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. Children who have a…[Read more]

As of February 26, six patients had a negative RT-PCR for 2019-nCoV and were discharged. The median time from exposure to a negative RT-PCR was 14 days. CONCLUSIONS The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. Children who have a…[Read more]